C-PECs used for non-sterile compounding include which combination?

• A. Class 2 BSC / CVE / CACI
• B. Class 3 BSC / CVE / LAFW
• C. Class 1 or 2 BSC / CVE / CACI
• D. Laminar Airflow Workbench / CAI

Answer: (C)

Non-sterile hazardous-drug compounding relies on primary containment devices that keep aerosols and vapors from reaching the worker. The allowed C-PEC options for this setting include Class I or Class II biosafety cabinets, containment ventilated enclosures (CVE), and containment isolators like CACIs. A Class I BSC provides inward airflow to protect the worker; a Class II BSC offers protection for both the worker and the product. A CVE creates a negative-pressure, HEPA-filtered enclosure for contained work. A CACI gives a closed, glovebox-style environment to handle HD without releasing contaminants. Together, these cover the typical containment controls used for non-sterile HD compounding. Options that involve equipment not suited for HD containment, such as a Class III cabinet or a laminar airflow bench, aren’t appropriate for this purpose.