How should HDs be prepared for administration to minimize exposure?

• A. Prepare at bedside without PPE
• B. Use appropriate engineering controls (C-PEC or CSTDs), follow sterile technique, use PPE, and minimize aerosolization and splashes
• C. Use only manual methods
• D. Use non-sterile technique

Answer: (B)

The main idea is protecting workers by using containment and proper aseptic methods when preparing hazardous drugs. The best approach combines engineering controls, sterile technique, and appropriate personal protective equipment, with actions aimed at reducing any aerosol release or splashing.

Using an engineering containment device such as a closed-system transfer device (CSTD) or a compounding aseptic containment isolator (C-PEC) creates a barrier between the drug and the worker during all transfer and preparation steps. This minimizes the chance that drug aerosols or splashes escape into the surrounding environment. Pairing that with sterile technique ensures the preparation remains free of contaminants, protecting both patient and staff. Wearing the right PPE—appropriate gowns, gloves, and eye/face protection, and, when indicated, respiratory protection—adds another layer of defense.

Choosing not to use containment or PPE, or performing the work at the bedside, would expose staff to higher risk of contact or inhalation with hazardous drugs. Relying on manual methods alone or using non-sterile technique would increase both exposure and the potential for contamination, which is why they’re not appropriate options in this context.

So, the combination of engineering controls (CSTD or C-PEC), sterile technique, appropriate PPE, and methods that minimize aerosolization and splashes is the correct and best practice for preparing HDs for administration.