If a sterile HD is compounded in a CSCA, it must have a minimum of —— ACPH

• A. 12
• B. 6
• C. 8
• D. 20

Answer: (A)

ACPH measures how many times the room’s air is replaced each hour, which is crucial for diluting and removing airborne hazardous particles. When sterile hazardous drugs are compounded in a containment sterile compounding area, the system is designed to ensure enough air turnover to maintain containment and protect workers. The minimum is 12 ACPH in this CSCA setting, because this level provides adequate ventilation to dilute any potential aerosols and supports maintaining the required negative pressure relative to surrounding areas. Values like 6 or 8 ACPH would be too low to effectively remove contaminants, while 20 ACPH would exceed the minimum but isn’t required.