List essential PPE items recommended for handling hazardous drugs.

• A. Regular latex gloves, ordinary lab coat, safety glasses
• B. Chemo-rated gloves (often double), disposable chemo gown or sleeve covers, eye/face protection, shoe covers, and head cover as appropriate; change gloves and gown per SOP
• C. Respirator and full-body impermeable suit
• D. No PPE is required for HD handling

Answer: (B)

Handling hazardous drugs requires a barrier that protects against contact and splashes from cytotoxic agents. The best choice reflects the protective items designed specifically for this purpose: chemo-rated gloves, often worn in double layers, a disposable chemo gown or sleeve covers, eye or face protection, shoe covers, and a head cover as appropriate, with gloves and gown changed per the standard operating procedure. Chemo-rated gloves are tested for resistance to permeation by chemotherapy drugs, and wearing an outer glove over a second pair provides an extra line of defense if the outer layer is compromised. A disposable chemo gown or sleeve covers protects skin and clothing from splashes, while eye or face protection shields the eyes and mucous membranes from exposure. Shoe covers help prevent contamination from footwear and help keep the work area clean, and a head cover minimizes contamination from hair or scalp when appropriate. Changing gloves and gowns according to SOP ensures any permeation or soiled barriers are promptly replaced, maintaining the protective barrier throughout handling. Regular latex gloves and an ordinary lab coat do not provide the specialized barrier needed for HDs, and while more robust protection like a respirator and full-body impermeable suit is reserved for particular high-risk inhalation scenarios, it is not standard for routine HD handling.