Non-sterile compounding C-SEC requirements include which ventilation features?

• A. Internally vented, positive pressure, at least 12 ACPH
• B. Externally vented, positive pressure, at least 12 ACPH
• C. Internally vented, negative pressure, at least 12 ACPH
• D. Externally vented, negative pressure, at least 12 ACPH

Answer: (D)

The key idea is to ensure hazardous drug aerosols are contained and removed safely through the ventilation design of the containment secondary engineering control used for non-sterile compounding. The space must be negatively pressured relative to surrounding areas so that air flows into the room rather than out, preventing contaminated air from escaping into the rest of the facility. It should be externally vented so that any air exhausts directly outside the building, not recirculated back into the facility. And it needs at least 12 air changes per hour to provide adequate dilution and removal of any airborne contaminants produced during compounding. Together, externally vented, negative pressure with a minimum of 12 ACPH best ensures containment and protects staff and the environment.