Refrigerated antineoplastic HDs must be stored in a dedicated refrigerator in an environment with what conditions?

• A. Positive pressure
• B. Neutral pressure
• C. Negative pressure and at least 12 ACPH
• D. Negative pressure with 0 ACPH

Answer: (C)

A key protection concept is containment through proper ventilation. Refrigerated antineoplastic HDs should be kept in a dedicated refrigerator located in an area that is under negative pressure relative to surrounding spaces and has sufficient air exchange. Negative pressure pulls room air into the storage area rather than pushing it out, which helps keep any potential vapors or aerosols contained. At least 12 air changes per hour ensures the room’s air is refreshed frequently, diluting and removing any contaminants that might be released.

If the area were under positive pressure, contaminants could be drawn into adjacent spaces; neutral pressure offers no real containment; and negative pressure with zero air changes would not remove or dilute contaminants, increasing exposure risk.