What does SOP stand for, and how often is it updated?

• A. Standard Operating Protocol (update every 6 months)
• B. Standard Operating Procedure (update every 12 months)
• C. System Operating Procedure (update every 24 months)
• D. Standard Operations Procedure (update every 12 months)

Answer: (B)

SOP stands for Standard Operating Procedure. This term denotes a formal, step-by-step guide for performing tasks safely and consistently. The word “Procedure” is the standard choice here, not “Protocol,” “System,” or “Operations,” which is why those alternatives aren’t the best fit.

Updating it every 12 months means an annual review to keep the instructions current with safety best practices, regulatory requirements, and any changes in equipment or processes. In hazardous drug management, an SOP typically covers handling, compounding, storage, personal protective equipment, decontamination, spill response, and disposal. Regular annual updates help incorporate new guidelines (for example, evolving USP or institutional policy changes) and lessons learned from incidents or near-misses. While updates can occur sooner if a major change arises, the usual cadence is annual.