What PPE should be used for handling HDs during preparation?

• A. No PPE needed
• B. PPE such as gloves, gown, eye protection, and respirators as needed, with engineering controls
• C. Just gloves
• D. Only lab coat

Answer: (B)

Handling hazardous drugs during preparation requires protection for skin, eyes, and the respiratory tract, plus controls that reduce exposure at the source. The best approach is comprehensive PPE used in combination with engineering controls. This means wearing gloves that are resistant to chemotherapy drugs, a disposable impermeable gown with cuffs, and eye protection to shield against splashes. Respiratory protection should be used if there’s a risk of aerosolized exposure, chosen based on the specific drug and procedure and with proper fit. PPE works best when paired with engineering controls like containment devices or dedicated safety cabinets and closed-system transfer devices to minimize any potential release of drug onto the worker. Training on how to properly don and doff PPE and how to decontaminate surfaces is also essential to prevent contamination. Wearing no PPE, or only one item like gloves or a lab coat, does not provide sufficient protection for the risks involved.