Which statement about PPE change practices is accurate?

• A. Gloves should be changed every 60 minutes; gowns every 4 hours
• B. Gloves should be changed every 15 minutes; gowns every 1 hour
• C. Gloves should be changed every 30 minutes; gowns every 2-3 hours
• D. Gloves should be changed after each patient; gowns never

Answer: (C)

Protective barriers must be refreshed regularly to prevent exposure to hazardous drugs. Gloves are the primary line of defense against drug residues that can permeate or wear down with use, so changing them about every 30 minutes helps maintain a reliable barrier. If you notice any contamination, damage, or if you switch tasks or drugs, replace the gloves immediately and perform hand hygiene.

Gowns provide a broader protective cover, but they can become contaminated over time as well. Changing gowns every 2–3 hours preserves protection while keeping the process practical, and you should change them sooner if they become visibly soiled, splashed, or contaminated. Always remove and change PPE using proper technique to avoid self-contamination, and perform hand hygiene after doffing.

Intervals like changing gloves only every 60 minutes or only every 4 hours, or never changing gowns, do not align with the goal of maintaining continuous barrier protection and reducing transfer or exposure risk.