Which statement best describes the hazardous drugs commonly cited as hazardous due to antineoplastic activity?

• A. Methotrexate, cyclophosphamide, ifosfamide, cisplatin, fluorouracil, doxorubicin, paclitaxel are commonly cited as hazardous due to antineoplastic activity
• B. Not applicable
• C. Penicillin and amoxicillin are the primary hazardous drugs
• D. Insulin and heparin are the primary hazardous drugs

Answer: (A)

Cytotoxic chemotherapy drugs are hazardous because their antineoplastic activity can damage healthy cells as well as cancer cells, so strict handling is required to protect workers. The best statement lists well-known examples of these cytotoxic agents—methotrexate, cyclophosphamide, ifosfamide, cisplatin, fluorouracil, doxorubicin, and paclitaxel—which are consistently cited as hazardous due to their cancer-fighting (antineoplastic) activity. This reflects the emphasis on protecting staff from exposure to drugs with potent cytotoxic effects, not general drug hazards.

The other options don’t fit because penicillin and amoxicillin are antibiotics, and insulin and heparin are a hormone and an anticoagulant, respectively; neither category is identified primarily by antineoplastic, cytotoxic risk.